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Molecular Partners Demonstrates Tumor-Localized Immune Activation With Logic-Gated CD3 Switch-DARPin Inducing Significant Tumor Regression Without Systemic Cytokine Release

Benzinga·11/03/2025 07:13:45
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  • Poster presentation outlines potential of CD3 Switch-DARPin T cell engager (TCE) using an AND-gate to overcome limitations of other TCEs
  • Demonstrated selective T cell cytotoxicity against cells co-expressing tumor-associated antigens MSLN and EpCAM
  • Induced significant tumor regression in vivo without causing systemic cytokine release, indicating favorable safety profile