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Exelixis (EXEL) Valuation Check After Strong Multi‑Year Share Price Gains

Simply Wall St·12/08/2025 07:15:15
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Exelixis (EXEL) has quietly rewarded patient shareholders, with the stock up around 31% year to date and roughly 24% over the past year, outpacing many mid cap biotech peers.

See our latest analysis for Exelixis.

The latest leg higher has been driven less by headline grabbing news and more by steadily improving sentiment, with an 8.7% 1 month share price return feeding into a powerful three year total shareholder return above 180% that signals momentum is still very much on Exelixis' side.

If Exelixis has you rethinking your healthcare exposure, this is a good moment to explore other potential winners across healthcare stocks and see what else fits your strategy.

With Exelixis now brushing up against Wall Street’s price targets after a powerful multi year run, investors face a pivotal question: is there still meaningful upside left, or has the market already priced in the next leg of growth?

Most Popular Narrative: 1.4% Undervalued

With Exelixis closing at $44.36 against a narrative fair value near $45, the story leans toward modest upside driven by earnings power and cash returns.

The company's substantial free cash flow, strong balance sheet, and disciplined capital allocation (including aggressive share repurchases and prioritization of high probability, high value R&D programs) position Exelixis to invest in next generation discovery and strategic partnerships, which has the potential to improve operating leverage and net margins over time as the product portfolio scales.

Read the complete narrative.

Want to see what is really behind that tiny undervaluation gap? The narrative leans on ambitious earnings expansion, richer margins, and a surprisingly low future earnings multiple. Curious how those moving parts combine to justify today’s fair value target and long term upside potential? Dive in to see the full set of assumptions.

Result: Fair Value of $45 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, the narrative could quickly change if cabozantinib faces faster than expected erosion, or if key late stage pipeline trials underdeliver on efficacy or uptake.

Find out about the key risks to this Exelixis narrative.

Build Your Own Exelixis Narrative

If you see the story differently, or would rather dig into the numbers yourself, you can build a personalized view in just minutes: Do it your way.

A great starting point for your Exelixis research is our analysis highlighting 4 key rewards and 1 important warning sign that could impact your investment decision.

Looking for more investment ideas?

Before you move on, lock in an edge by scanning fresh opportunities across different themes, so you are not relying on a single stock story.

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.