Annovis Reveals Open-Label Extension Study For Parkinson's Disease Patients; To Begin Open-label Extension Study In January 2026; Participants Will Be Treated With Buntanetap For 36 Months

Annovis Bio, Inc. (NYSE:ANVS) ("Annovis" or the "Company"), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced it will begin an Open-Label Extension (OLE) study in January 2026 to evaluate the long-term safety and efficacy of buntanetap in PD patients.

"Launching the OLE study is a natural next step for our Parkinson's program," said Maria Maccecchini, Ph.D., President and CEO. "In our previous PD trial, many patients shared they experienced noticeable improvements and were eager to stay on treatment. Being able to offer them continued access to buntanetap truly matters to us."

"At the same time, this study will allow us to take a longer-term view of buntanetap," she continued. "By following patients over an extended period, we will further measure buntanetap's safety and evaluate its sustained benefits on both motor and cognitive functions. Collecting biomarker data will also help us deepen our understanding of buntanetap's potential as a disease-modifying treatment."