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Metagenomi reports compact CRISPR nuclease MG119-28 shows higher genome-editing efficiency

PUBT·04/16/2026 11:01:40
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Metagenomi reports compact CRISPR nuclease MG119-28 shows higher genome-editing efficiency
  • Metagenomi published results in Nature Structural & Molecular Biology on April 16, 2026, detailing MG119-28, a compact Cas12f CRISPR nuclease with higher genome-editing efficiency than earlier compact nucleases.
  • Study attributed performance gains to higher protein structural stability and a more stable guide RNA, supporting faster DNA cleavage.
  • Researchers used structural and mechanistic findings to engineer MG119-28 for improved activity across multiple target genes.
  • Metagenomi positioned MG119-28 as a step toward AAV-deliverable in vivo editing beyond liver targets, including potential neuromuscular disease applications.
  • Company highlighted prior 2025 ASGCT mouse data showing 64% knockdown of Atxn2 protein from a single AAV delivering MG119-28 with a targeting guide.


Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Metagenomi Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: 202604160700PRIMZONEFULLFEED9690960) on April 16, 2026, and is solely responsible for the information contained therein.