On July 22, Li Ming's team from the Institute of Microbiology of the Chinese Academy of Sciences and Zhang Yan of the University of Michigan collaborated to publish a research paper entitled “CRISPR-Cas Intervented Expression of Embedded Anti-Phage Defence Systems” in Nature. For the first time, the study revealed the cooperative regulation mechanism between adaptive immunity and innate immunity in prokaryotes, providing a new perspective for understanding the evolution and interaction of living immune systems. The study not only proposed a theoretical framework for the first time that two types of immunity cooperate and protect each other at the level of prokaryotic life, but also established a new discovery path for novel immune systems based on this original theory, and systematically identified a series of novel immune elements, including prokaryotic caspase protease and novel nucleases. The discovery of these new components not only provides new knowledge and tools for in-depth understanding and intervention in innate immunity in higher life, but is also expected to provide key component resources for innovation in underlying molecular technology.

On July 22, Li Ming's team from the Institute of Microbiology of the Chinese Academy of Sciences and Zhang Yan of the University of Michigan collaborated to publish a research paper entitled “CRISPR-Cas Intervented Expression of Embedded Anti-Phage Defence Systems” in Nature. For the first time, the study revealed the cooperative regulation mechanism between adaptive immunity and innate immunity in prokaryotes, providing a new perspective for understanding the evolution and interaction of living immune systems. The study not only proposed a theoretical framework for the first time that two types of immunity cooperate and protect each other at the level of prokaryotic life, but also established a new discovery path for novel immune systems based on this original theory, and systematically identified a series of novel immune elements, including prokaryotic caspase protease and novel nucleases. The discovery of these new components not only provides new knowledge and tools for in-depth understanding and intervention in innate immunity in higher life, but is also expected to provide key component resources for innovation in underlying molecular technology.