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    Does Arcus Biosciences’ (RCUS) AVEO Tie-Up Hint At A New Combo-First RCC Strategy?

    Simply Wall St·07/24/2026 16:39:34
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    • Arcus Biosciences recently announced a clinical supply agreement with AVEO Oncology to test its investigational HIF-2α inhibitor casdatifan in combination with AVEO’s tivozanib in a new ARC-20 study cohort for patients with advanced clear cell renal cell carcinoma who previously received HIF-2α inhibitor therapy.
    • An interesting aspect of this collaboration is that both companies retain development and commercial rights to their respective drugs, potentially influencing how future combination therapies are advanced and monetized in renal cancer.
    • We’ll now examine how adding a post–HIF-2α inhibitor renal cancer cohort with tivozanib may influence Arcus Biosciences’ investment narrative.

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    Arcus Biosciences Investment Narrative Recap

    To own Arcus Biosciences, you need to believe casdatifan and the broader oncology pipeline can convert promising data into approved products before cash burn and competition bite too hard. The new AVEO tivozanib combination cohort adds breadth to casdatifan’s RCC story, but it does not clearly change the key near term catalyst, which remains upcoming casdatifan data readouts, or the central risk around regulatory outcomes and continued operating losses.

    The AVEO collaboration fits alongside Arcus’s June 2026 agreement with Bristol Myers Squibb to test casdatifan with pumitamig in the ROSETTA RCC-208 study. Together, these partnerships broaden casdatifan’s combination portfolio in renal cancer just as investors are watching how Arcus manages high clinical spend, partner dependencies, and a revenue base that was only US$17,000,000 in Q1 2026.

    Yet while the RCC partnerships expand options for Arcus, investors still need to be aware of the risk that...

    Read the full narrative on Arcus Biosciences (it's free!)

    Arcus Biosciences’ narrative projects $223.2 million revenue and $42.2 million earnings by 2029. This implies revenues will decline by 1.8% per year and requires an earnings increase of about $411 million from -$369.0 million today.

    Uncover how Arcus Biosciences' forecasts yield a $35.75 fair value, a 20% upside to its current price.

    Exploring Other Perspectives

    RCUS 1-Year Stock Price Chart
    RCUS 1-Year Stock Price Chart

    Some analysts were already assuming roughly 50 percent annual revenue growth and US$150,000,000 in 2029 earnings, so this new RCC combo could either reinforce those optimistic expectations or highlight how uncertain partner dependence and trial outcomes really are for you as a shareholder.

    Explore 3 other fair value estimates on Arcus Biosciences - why the stock might be worth just $35.75!

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.