Prothena publishes corporate overview presentation on protein-dysregulation drug pipeline

• Prothena highlighted partnered late-stage programs, led by Roche’s Phase 3 prasinezumab trial in early Parkinson’s disease, with primary completion expected in 2029.
• Novo Nordisk’s coramitug (PRX004) in ATTR cardiomyopathy remains in Phase 3, with CLEOPATTRA ongoing and primary completion expected in 2029.
• Bristol Myers Squibb-linked PRX019 completed Phase 1; Prothena flagged a potential $55 million milestone tied to a development decision by year-end 2026.
• Prothena also pointed to up to $105 million in clinical milestones by year-end 2026, including a $50 million Phase 3 enrollment milestone for coramitug.
• Shareholder returns included $22.3 million of repurchases in the first half of 2026 under a program authorizing up to $100 million through Dec. 31, 2026.

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