Roche says Phase III IMAgINATION trial shows sefaxersen cuts proteinuria in IgA nephropathy patients

• Roche reported positive interim Phase III data for Genentech’s sefaxersen in adults with primary IgA nephropathy.
• The trial met its primary goal, showing a meaningful reduction in protein in urine versus placebo, supporting potential disease-slowing benefit.
• Results have not yet been presented; the interim analysis is slated for an upcoming medical meeting.
• The study continues blinded to assess longer-term kidney function over two years, a key determinant for regulatory and commercial outlook.

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