Bruker says timsTOF mass spectrometry maps 179,000 human plasma proteoforms in draft atlas

• Bruker highlighted a bioRxiv preprint describing a draft human plasma proteome atlas mapped at proteoform resolution using timsTOF systems.
• Researchers reported 5,077 plasma protein groups across 179,049 proteoforms; a high-confidence set covered 44,083 proteoforms.
• Work used intact-protein fractionation with diaPASEF, targeting higher-throughput proteoform discovery without nanoparticle-based enrichment.
• Results point to broader protein diversity than canonical protein lists, a factor that can drive mismatches across proteomics measurement platforms.
• Bruker also flagged the timsOmni platform for deeper top-down proteoform sequencing, positioning it for biomarker and drug-target research workflows.

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