AbbVie says Phase 3 AFFIRM study shows subcutaneous Skyrizi beats placebo on Crohn’s remission, endoscopic response at week 12

• AbbVie flagged new Crohn’s disease results for SKYRIZI from its Phase 3 AFFIRM study, set for presentation at ACG 2026.
• AFFIRM showed patients on subcutaneous SKYRIZI achieved better disease control than placebo, with benefits holding through maintenance follow-up.
• Separate extension analyses to be shown at the meeting indicate SKYRIZI can sustain long-term bowel healing in harder-to-treat patients.
• Real-world studies scheduled for ACG also point to disease control with RINVOQ in advanced Crohn’s disease, including complex fistulizing cases.

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