Pinnacle Food's AgTech Unit Completes First Bench-Scale Fermentation Of Recombinant Human Lactoferrin Yeast Strain

Pinnacle Food Group Limited (NASDAQ:PFAI) ("Pinnacle Food" or the "Company"), a technology-driven company operating at the intersection of smart farming and bioengineering, today announced that its wholly owned subsidiary, Pinnacle Food AgTech HK Limited ("PFHK"), has successfully completed the first bench-scale fermentation of the Company's first-generation recombinant human lactoferrin ("rhLF") yeast strain in a 5-liter bench-scale fermenter.

Laboratory analyses, including high-performance liquid chromatography (HPLC), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Immuno Blotting, confirmed rhLF expression. The fermentation was conducted using the methanol-free Pichia fermentation technology developed under the Company's research collaboration with Bioboost Synbio Consulting Inc. ("Bioboost"). This methanol-free approach is designed to offer a cleaner, safer and more cost-effective alternative to conventional methanol-based fermentation approaches.

The milestone builds on the Company's April 2026 announcement of the creation of its first-generation rhLF yeast strain and marks the first evaluation of that strain under controlled bench-scale fermentation conditions. The results further inform strain optimization and process development, and support the Company's evaluation of potential scale-up.

Lactoferrin is an iron-binding glycoprotein naturally present in milk, including human milk, and is used as an ingredient in infant nutrition, dietary supplements and other nutritional applications. Recombinant human lactoferrin (rhLF) that is produced through precision fermentation is intended to be structurally similar to the lactoferrin found in human milk.