Trevi Therapeutics Intends To Start Phase 2b Study In Participants With Refractory Chronic Cough In H1 2026, Company's Chronic Cough In Idiopathic Pulmonary Fibrosis Granted End-Of-Phase 2 Meeting With FDA

Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (non-IPF ILD), and refractory chronic cough (RCC), today announced strategic updates ahead of its participation in the 15th Annual LifeSci Partners Corporate Access Event taking place in San Francisco, CA, from January 12-14, 2026. This event will be held during the week of the annual J.P. Morgan Healthcare Conference.

• Chronic Cough in IPF
  • The Company was granted an End-of-Phase 2 meeting by the FDA, scheduled to take place in the first quarter of 2026. This meeting will discuss the clinical development and regulatory pathway for the New Drug Application of nalbuphine ER for the treatment of chronic cough in patients with IPF. Following this meeting, the Company expects to initiate its Phase 3 program of nalbuphine ER in this patient population in the first half of 2026.
• Refractory Chronic Cough
  • The Company plans to initiate a Phase 2b trial in patients with RCC in the first half of 2026.
• David Hastings, the new Chief Financial Officer for Trevi Therapeutics, will attend the LifeSci Partners Corporate Access Event along with other members of the senior management team.