Natera Advances Molecular Residual Disease-Based Risk Stratification With New Multi-Model

Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA (cfDNA) testing and precision medicine, today announced an advancement in molecular residual disease (MRD)-based risk stratification that is expected to extend the company's leadership in oncology. The new multi-modal model will integrate longitudinal ctDNA and clinical data with digital pathology imaging and tumor sequencing data, to enhance the Signatera™ MRD assessment.

Signatera has transformed cancer management by enabling ultra-sensitive MRD detection and informing more personalized treatment decisions. The multi-modal approach leverages additional information from the patient's tumor sample, using Natera's AI models trained on long-term molecular and clinical outcomes from Natera's proprietary database of approximately 300,000 patients tested with Signatera since launch. The approach shows statistically and clinically significant enhancements, with data expected to be presented at an upcoming conference ahead of launches in the research and clinical settings.